[et_pb_section fb_built=“1″ next_background_color=“#ffffff“ _builder_version=“4.16″ _module_preset=“default“ background_image=“https:\/\/caro-gard.cz\/wp-content\/uploads\/2021\/12\/zahlavi_pozadi.png“ min_height=“304.2px“ bottom_divider_style=“slant“ bottom_divider_flip=“horizontal“ global_colors_info=“{}“][et_pb_row _builder_version=“4.16″ _module_preset=“default“ custom_margin=“|auto|-59px|auto||“ global_colors_info=“{}“][et_pb_column type=“4_4″ _builder_version=“4.16″ _module_preset=“default“ global_colors_info=“{}“][et_pb_text _builder_version=“4.25.2″ _module_preset=“default“ text_font=“Inria Serif|700|||||||“ text_text_color=“#FFFFFF“ text_font_size=“30px“ text_line_height=“1.3em“ header_font=“Inria Serif|700|||||||“ header_text_align=“left“ header_text_color=“#FFFFFF“ header_line_height=“1.2em“ header_2_font=“Inria Serif||||||||“ header_2_text_color=“#FFFFFF“ header_2_font_size=“24px“ header_2_line_height=“1.2em“ header_6_font=“Inria Serif|700|||||||“ header_6_text_color=“#FFFFFF“ header_6_font_size=“16px“ header_6_line_height=“4.7em“ background_enable_image=“off“ max_width=“70%“ max_width_tablet=“70%“ max_width_phone=“90%“ max_width_last_edited=“on|phone“ header_font_size_tablet=“40px“ header_font_size_phone=“25px“ header_font_size_last_edited=“on|phone“ header_2_font_size_tablet=“24px“ header_2_font_size_phone=“20px“ header_2_font_size_last_edited=“on|phone“ header_6_font_size_tablet=“16px“ header_6_font_size_phone=“14px“ header_6_font_size_last_edited=“on|phone“ global_colors_info=“{}“]<\/p>\n
<\/p>\n<\/div>\n<\/div>\n<\/div>\n
[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=“1″ _builder_version=“4.16″ _module_preset=“default“ global_colors_info=“{}“][et_pb_row _builder_version=“4.16″ _module_preset=“default“ min_height=“1238.4px“ custom_margin=“-43px|auto||auto||“ global_colors_info=“{}“][et_pb_column type=“4_4″ _builder_version=“4.16″ _module_preset=“default“ global_colors_info=“{}“][et_pb_text _builder_version=“4.25.2″ _module_preset=“default“ text_font=“Open Sans||||||||“ text_text_color=“#404040″ text_font_size=“16px“ header_3_font=“Inria Serif|700|||||||“ header_3_text_color=“#0082AD“ header_3_line_height=“1.4em“ header_4_font=“Inria Serif||on||||||“ header_4_text_color=“#0082AD“ header_4_font_size=“20px“ header_4_line_height=“1.3em“ header_6_font=“Inria Serif|700|||||||“ header_6_text_color=“#DF428B“ max_width=“80%“ max_width_tablet=“80%“ max_width_phone=“100%“ max_width_last_edited=“on|phone“ global_colors_info=“{}“]<\/p>\n
Prvn\u00ed centrum na Morav\u011b, kter\u00e9 bude l\u00e9\u010dit genetick\u00e9 onemocn\u011bn\u00ed, otev\u00edr\u00e1 v dubnu dve\u0159e pacient\u016fm. Do brn\u011bnsk\u00e9 fakultn\u00ed nemocnice, na \u201eplicn\u00ed“ kliniku, si nov\u011b mohou p\u0159ij\u00edt pro \u00falevu nemocn\u00ed, jim\u017e chyb\u00ed tzv. alfa-1 antitrypsin (AAT). To je l\u00e1tka, kter\u00e1 chr\u00e1n\u00ed pl\u00edce p\u0159ed zni\u010den\u00edm a p\u0159ed rozvojem \u0159ady plicn\u00edch nemoc\u00ed. Dosud byli pacienti odk\u00e1z\u00e1ni na jedin\u00e9, p\u0159et\u00ed\u017een\u00e9 centrum v Praze, kde na term\u00edn \u010dekali i m\u011bs\u00edce. To se nyn\u00ed m\u011bn\u00ed.<\/strong><\/p>\n \u00a0<\/strong>\u201eU\u017e v dubnu p\u0159ij\u00edm\u00e1me prvn\u00ed pacienty, u nich\u017e se deficit enzymu AAT projevil. V\u011bt\u0161ina z nich je ve st\u0159edn\u00edm v\u011bku a trp\u00ed pokro\u010dil\u00fdmi formami plicn\u00edch chorob \u2013 nej\u010dast\u011bji chronickou obstruk\u010dn\u00ed plicn\u00ed nemoc\u00ed. Pravideln\u00e1 l\u00e9\u010dba pomoc\u00ed n\u00e1hrady proteinu nemocn\u00fdm ulev\u00ed. Zastavuje toti\u017e postup nemoci, kter\u00e1 se kv\u016fli deficitu AAT rozvinula,“<\/em> vysv\u011btluje doc. MUDr. Milan Sova, Ph.D., p\u0159ednosta Kliniky nemoc\u00ed plicn\u00edch a tuberkul\u00f3zy FN Brno.<\/p>\n Podle pneumolog\u016f o tom, \u017ee maj\u00ed m\u00e1lo nebo \u017e\u00e1dn\u00fd AAT, v\u011bt\u0161ina lid\u00ed nev\u00ed. P\u0159itom hladinu t\u00e9to l\u00e1tky lze vy\u010d\u00edst z krve. Ti, kte\u0159\u00ed nedostatkem trp\u00ed, se obvykle pot\u00fdkaj\u00ed s nejr\u016fzn\u011bj\u0161\u00edmi plicn\u00edmi chorobami, a to u\u017e v mlad\u00e9m v\u011bku \u2013 kolem t\u0159ic\u00edtky. Jak rychle se nemoci projev\u00ed, z\u00e1le\u017e\u00ed i na dal\u0161\u00edch faktorech, jako je kou\u0159en\u00ed nebo \u017eivotn\u00ed styl. \u201eRiziko posti\u017een\u00ed plic ovliv\u0148uje i hladina enzymu \u2013 plat\u00ed, \u017ee \u010d\u00edm je ni\u017e\u0161\u00ed, t\u00edm je pravd\u011bpodobnost onemocn\u011bn\u00ed vy\u0161\u0161\u00ed. Zpozorn\u011bt by tak m\u011bli v\u0161ichni, kdo se v ml\u00e1d\u00ed nebo st\u0159edn\u00edm v\u011bku pot\u00fdkaj\u00ed s t\u011b\u017ek\u00fdm astmatem, bronchiekt\u00e1ziemi nebo pr\u00e1v\u011b CHOPN \u2013 m\u011bli by proj\u00edt testy na hladinu AAT. Odhadujeme, \u017ee na Morav\u011b tuto nemoc prok\u00e1\u017eeme a n\u00e1sledn\u011b budeme l\u00e9\u010dit u ni\u017e\u0161\u00edch des\u00edtek osob,“<\/em> vysv\u011btluje doc. Sova. Test z krve mohou prov\u00e9st pneumologov\u00e9, prakti\u010dt\u00ed l\u00e9ka\u0159i nebo alergologov\u00e9.<\/p>\n Brn\u011bnsk\u00e9 centrum, kter\u00e9 \u010derstv\u011b z\u00edskalo \u00fahradu l\u00e9k\u016f od v\u011bt\u0161iny zdravotn\u00edch poji\u0161\u0165oven, je otev\u0159eno nejen pacient\u016fm z Moravy. \u201eI kdy\u017e p\u0159edpokl\u00e1d\u00e1me, \u017ee t\u011bch u n\u00e1s bude nejv\u00edce,“<\/em> dod\u00e1v\u00e1 doc. Sova.<\/p>\n Nemocn\u00ed s nedostatkem AAT se mohou l\u00e9\u010dit jenom v akreditovan\u00fdch centrech. Nyn\u00ed jsou v republice dv\u011b \u2013 v Praze a nov\u011b v Brn\u011b. Podle odhad\u016f trp\u00ed v \u010cesk\u00e9 republice nedostatkem AAT p\u0159ibli\u017en\u011b 1 % v\u0161ech pacient\u016f s chronickou obstruk\u010dn\u00ed plicn\u00ed nemoc\u00ed (CHOPN m\u00e1 v \u010cesku p\u0159ibli\u017en\u011b 700 000 lid\u00ed). Pacienty s deficitem AAT sleduj\u00ed odborn\u00edci v n\u00e1rodn\u00edm registru.<\/p>\n O nemoci:<\/strong> [\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":" V Brn\u011b vzniklo centrum, kde l\u00e9\u010d\u00ed genetickou vadu. Ulev\u00ed nemocn\u00fdm, kte\u0159\u00ed maj\u00ed posti\u017een\u00e9 pl\u00edce Prvn\u00ed centrum na Morav\u011b, kter\u00e9 bude l\u00e9\u010dit genetick\u00e9 onemocn\u011bn\u00ed, otev\u00edr\u00e1 v dubnu dve\u0159e pacient\u016fm. Do brn\u011bnsk\u00e9 fakultn\u00ed nemocnice, na \u201eplicn\u00ed“ kliniku, si nov\u011b mohou p\u0159ij\u00edt pro \u00falevu nemocn\u00ed, jim\u017e chyb\u00ed tzv. alfa-1 antitrypsin (AAT). To je l\u00e1tka, kter\u00e1 chr\u00e1n\u00ed pl\u00edce […]<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","_monsterinsights_skip_tracking":false,"footnotes":""},"class_list":["post-1072","page","type-page","status-publish","hentry"],"aioseo_notices":[],"aioseo_head":"\n\t\t\n\t\n\t\n\t\n\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t\n\t\t
Deficit alfa-1 antitrypsinu (AAT) je d\u011bdi\u010dn\u00e9 onemocn\u011bn\u00ed zp\u016fsoben\u00e9 sn\u00ed\u017eenou hladinou (nebo \u00faplnou absenc\u00ed) tohoto enzymu v krvi. Hlavn\u00edm projevem deficitu AAT je rozedma plic, jin\u00fdmi slovy emfyz\u00e9m nebo CHOPN. Riziko posti\u017een\u00ed plic z\u00e1le\u017e\u00ed na hladin\u011b enzymu v krvi \u2013 \u010d\u00edm je ni\u017e\u0161\u00ed, t\u00edm je riziko onemocn\u011bn\u00ed v\u011bt\u0161\u00ed. Pl\u00edce v\u0161ak nejsou jedin\u00fdm org\u00e1nem, kter\u00fd m\u016f\u017ee b\u00fdt posti\u017een. Relativn\u011b \u010dasto jsou posti\u017eena j\u00e1tra, asi t\u0159etina nemocn\u00fdch je ohro\u017eena v\u00fdvojem cirh\u00f3zy jater. Posti\u017een\u00ed jin\u00fdch org\u00e1n\u016f je vz\u00e1cn\u00e9, ale lze se setkat s posti\u017een\u00edm k\u016f\u017ee, st\u0159ev nebo jin\u00fdch org\u00e1n\u016f. V\u00edce informac\u00ed na https:\/\/www.alfa1.cz.<\/p>\n